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My Father and I both Canadian Citizens were denied to board a direct Turkish airlines flight from Istanbul to Toronto non-stop without any prior warning or information literally at the gate, we were told that we were put on a no fly list by homeland security because my father and I own a cargo business together located in eastern Turkey, apparently the area was suddenly declared a red zone (danger zone) and all business owners in district were put on a no fly list. The only way we were able to make it back to Canada was via Scandinavian northern routes flying close to the arctic. Cost thousands of dollars hundreds of hours and and months in moral and mental pain. We even had a issue sending my 1 year old daughter on a flight with her mother to visit Turkey after that I was told my one year old daughters name was put on a no fly list, when i heard this i just felt like fainting and was holding my self not to cry in front of all these people. On top of all of this even when we are able to fly back and forth via 2-3 stop northern routs to Canada we are now getting interrogated for 4-5 hour periods at our own airports by our own Canadian customs agents every single time. life has been horrible with this issue handicapping us to live our normal lives. We are honest business people that have nothing to do with any illegal acts we have always been law abiding citizens and will continue to do so.

Can anyone Help with this issue has anyone every had any similar experience ? any resolution ?

As you've discovered, US regulations apply not just to flights to or from the US, but also to flights that pass over the US. Before such flights the airline will send APIS data (basically the details of the everyone on the flight) to the US Government, who can flag certain passengers as appears to have happened here.

Your only real recourse is to apply to the US Department of Homeland Security Traveler Redress Inquiry Program (TRIP). This will trigger the DHS to investigate you specifically, and if they determine that you should not have been blocked from boarding (which could be as simply as them confusing you with someone else, poor data on their behalf, etc) then they will remedy this.

As a part of the TRIP process you will be given a "Redress number" which can be used on future bookings, and will allow the government to match up your TRIP application and determination with your flight.

Of course, it's very possible that the DHS will determine that you are on a blacklist, and that fact is justified, in which case there's really nothing more that can be done.

Unfortunately if you’re on a USA no fly list, and you’re not a citizen or permanent resident, you have very little recourse.

Who Can Challenge the No-Fly List?

In 2014, the American Civil Liberties Union obtained a federal court
ruling that U.S. citizens and lawful permanent residents were entitled
to know if they were on the list and potentially know what got them
there. Baz’s case, if successful, could extend that right to foreign
nationals.

Even if this case is successful, in your case you’re not someone who has been coming to the U.S. and has a long history of coming to the United States and has significant ties to the United States.